Application of Molecular Mimicry to Target GD2 Ganglioside
نویسندگان
چکیده
GD2 ganglioside is an important example of tumour-associated carbohydrate antigens. Over expression of the GD2 ganglioside is a hallmark of neuroblastoma, while its expression on normal cells is restricted. The antigen is stably expressed on cells of the tumour, and retained during a therapy of the disease (Kramer et al., 2001). The facts allow to use its presence to diagnose neuroblastoma, monitor response to treatment, and target the tumour cells (Navid et al., 2010; Reuland et al., 2001; Swerts et al., 2005).
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